Probably... We'd need to see the code first, though (supply us with a link).
The only IE thing that becomes extreemly problematic for other browsers is when ActiveX objects are used. However for the most part, js code can be made browser non-specific using hacks / work-arounds for IE-specific stuff.
If you want answers, write a smart question
, someone probably does know how...
Oh, and if you want to learn, STFW