Wow, I actually love the design!
A few things I would change:
• I don't like how the white space on the outside of the slideshow goes black every time the slide changes. It seems too distracting.
• The dropdown boxes could be a bit darker to fit the header better.
• The forward/next buttons on the slideshow should point left/right in my opinion. At first I wasn't sure what to click to change slides.
• The alignment of some of the boxes gets out of whack, which annoys my inner OCD self: http://i54.tinypic.com/2qxnfvs.jpg
• A favicon wouldn't hurt!