I doubt that this is possible. You canít edit a page in an inline frame from the containing document unless perhaps you control both the containing and framed documents. Allowing you to do otherwise would be a security issue for the framed Web site. I believe that someone asked the opposite of what you propose (forcing iframed links to open in a new window) and there werenít any solutions.
For every complex problem, there is an answer that is clear, simple, and wrong.