Thanks for all the comments!
I've used my first option.
<p>col up left</p>
<p>col up right</p>
<blockquote>middle quote</blockquote>
<p>col bot left</p>
<p>col bot right</p>
p {float: left; width: 450px}
p:nth-child(odd) {margin: 0 20px 0 0;}
blockquote {width: 920px; margin: 20px 0;}
Thanks.
Ilja