Depends on *HOW* you are trying to connect.
Are you using PHP?
Or just a command line interface to MySQL?
With old style PHP mysql_connect, your method should work.
With mysqli_connect, the port is specified separately.
With command line, you would use something like
mysql -uUSER -pPASSWORD -h220.127.116.11 -P443
So explain HOW you are trying to connect.
NOTE: Since 443 is probably a secure port, you may need to specify the --ssl
option as well.