Or if your server does not allow set_time_limit() you can set up cron jobs to send to groups at a set time for each (??? did you understand that?)
void set_time_limit ( int $seconds )
Set the number of seconds a script is allowed to run. If this is reached, the script returns a fatal error. The default limit is 30 seconds or, if it exists, the max_execution_time value defined in the php.ini.
When called, set_time_limit() restarts the timeout counter from zero. In other words, if the timeout is the default 30 seconds, and 25 seconds into script execution a call such as set_time_limit(20) is made, the script will run for a total of 45 seconds before timing out.