To be able to visit
http://artsite and have it display the site located in
I:/Documents and Settings/Ralph/My Documents/My Sites/artsite/public.
http://artsite/xamppand displays XAMPP's local site's home page as if I were visiting http://localhost.
To achieve expected behavior by either editing hosts and httpd-vhosts.conf. And if possible, to use a PAC file opposed to using the hosts file and also using dynamic virtual hosts opposed to continually editing the httpd-vhosts.conf. This is how I've done it previously just can't get it to work as previous.
It may look something like this:
I:/Documents and Settings/Ralph/My Documents/My Sites/%0/public
<Directory "I:/Documents and Settings/Ralph/My Documents/My Sites">
Allow from all
DocumentRoot "I:/Documents and Settings/Ralph/My Documents/My Sites/artsite/public"