I've got this computer that has worked fine for a long period of time. All of a sudden the mouse wouldn't work. I then realized neither what the keyboard or the NIC. It was then that I realized none of the inputs worked.
As soon as I boot into the machine I can use both a keyboard and mouse and everything is recognized. I can get into the BIOS and I can boot in safe mode.
Weather the machine is in safe mode or not as soon as Windows is booted the machine wont recognize any input devices.